Given that increased liver fat, IMCL [ 7475 ], and inflamed [ 76 ] and fibrotic adipose tissue [ 77 ] are associated with increased whole body insulin resistance, it is possible that NEFA are the link between ethnic differences in ectopic fat, inflammation, and risk for T2DM. Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Thank you all for the constant love and support. Kohli S, Lear SA. The authors noted that ethnicity did not modify the relationship between NEFA and insulin resistance, which was surprising given that AAs have a lower insulin sensitivity than Caucasians [ 79 ]. Part II of II. Customer Reviews New Wave of Podcasting. Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. This is a large prospective cohort study showing that Asians have the highest prevalence and incidence of diabetes among all ethnic groups, including AA and Latinos.
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This is the first study to show that some obese youth with and without T2DM have impaired suppression of lipolysis, demonstrating that adipose tissue insulin resistance occurs in obese adolescents.
Specifically, SAT biopsies performed in Caucasian, AA, Latino, and NA adults have shown that, in addition to elevations in plasma markers of inflammation, increases in pro-inflammatory immune cells in adipose tissue and elevated levels of fibrosis are associated with systemic and local inflammation [ 66 — 69 ].
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Metabolic Basis of Ethnic Differences in Diabetes Risk in Overweight and Obese Youth
However, these relationships do not necessarily explain ethnic differences in insulin resistance, since AAs have lower levels of VAT than Caucasians and Latinos [ 202526 ] yet are more insulin resistant [ 4 ].
Studies in obese adults have documented a relationship between decreased insulin suppression of lipolysis in adipose tissue, NEFA, and T2DM [ 72 ].
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Native American NA adolescents have a higher prevalence of obesity than those in all other races combined [ 23 ].
Additionally, increases in VAT in NA adults do not explain insulin resistance and hyperinsulinemia when compared to equally obese Caucasians [ 27 ]. Shout out to the good food and liquor that The Point of It All Podcast.
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Hyperinsulinemia in african-american children:
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|Plus; E-Mails and Fast Food River was on one this week, we all were!!!
This week we tackled some e-mails including accepting a marriage proposal knowing Picking up where we left off from Episode 61, 3 bottles of Sangria down and alot more to talk about, We discuss flirty bosses, Lying significant others, The dangerous game of not pulling out and is Funner a word?
The authors noted that ethnicity did not modify the relationship between NEFA and insulin resistance, which was surprising given that AAs have a lower insulin sensitivity than Caucasians [ 79 ].