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Inshe moved to the Sanger Institute, where she focused on the genomic epidemiology of complex traits. The Greek born biomedical scientist Eleftheria Zeggini is an internationally renowned expert in big data analysis and well known speaker and opinion leader in the field of translational genomics. In addition, they performed similar experiments using nucleosome complexes containing modified and unmodified histones as bait. Computational Neurocience The new, highly dynamic research discipline of Computational Neuroscience takes up these challenges. Together, mathematicians, physicists, biologists, psychologists, physicians and engineers identify principles of brain function and translate them into a mathematical representation. The focus is on the so-called "histone proteins" on which the DNA strands are wound and which can determine whether a gene can be read or not.

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  • Press Release – Helmholtz Zentrum München

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    The German Bernstein Network will be at the forefront of this endeavour. Imprint De utsch En glish.

    Eleftheria Zeggini has published hundreds of publications, frequently as lead author in top journals such as Nature, Nature Genetics and Science.

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    The brain is the seat of all mental functions. It combines biomedical experiments with theoretical models and thereby opens new avenues for scientific insights and technological applications. In addition, the scientists are examining the connections between common diseases and distortions in DNA packing.

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    This technique is thus novel in its revelation of the proteome-wide binding landscape of proteins that recognise particular DNA sequences or nucleosome states. Imprint De utsch En glish. Vimeo, Twitter, Googlemaps Permit embedded content and cookies from third party providers. To date, technical systems have not even come close to the swift and robust performance of the living brain. Major discoveries resulting from the work of Zeggini and her team have uncovered specific genomic alterations in musculoskeletal and metabolic diseases such as osteoarthritis and diabetes.

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    Necessary cookies Only cookies permitted that are required for the basic functionality of our websites. Computational Neuroscience will help to soothe the devastating effects of neurological diseases and aging, by developing new approaches for therapies and testing them safely in computer simulations, restoring challenged brain functions by new, intelligent implants and prostheses, and developing intelligent technical devices with brain-inspired sensors that take care of complex tasks in a reliable and safe way.

    This technique is thus novel in its revelation of the proteome-wide binding landscape of proteins that recognise particular DNA sequences or nucleosome states. The quantitative technique works by exposing short sequences of DNA oligonucleotides to nuclear extracts.

    As histone modifications can change chromatin structure and lead to changes in gene expression, this use of the technique allows the identification of biologically relevant interactions under different conditions.

    Third party content and cookies e. The brain is the seat of all mental functions.

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    The technique that we have developed now allows us to quantify binding events such as the interaction of nucleosome remodelling complexes with nucleosomes depending on the modifications that these are decorated with.

    Helmholtz - Gemeinschaft Deutscher Forschungszentren. Our extensive epidemiology program that includes leadership of the German National Cohort NAKO along with our ambitious new initiatives in applied artificial intelligence and digital health will now offer Professor Zeggini synergistic opportunities to accelerate her research.

    As histone modifications can change chromatin structure and lead to changes in gene expression, this use of the technique allows the identification of biologically relevant interactions under different conditions.

    Statistical cookies Matomo Permit cookies that help us to analyse the page views and user behavior on our websites. Major discoveries resulting from the work of Zeggini and her team have uncovered specific genomic alterations in musculoskeletal and metabolic diseases such as osteoarthritis and diabetes.

    This technique is thus novel in its revelation of the proteome-wide binding landscape of proteins that recognise particular DNA sequences or nucleosome states.

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    We use cookies to improve your experience on our Website. Computational Neuroscience research will change our life. Further Information Please find more details about the research of Eleftheria Zeggini and her team on the website of the Institute of Translational Genomics.

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    Press Release – Helmholtz Zentrum München

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    The same kind of models can also be used for investigating complex neurological malfunctions.

    Please find more information in our privacy statement. We only use this information for improving our services. The German Bernstein Network will be at the forefront of this endeavour. Contact for the media. There you may also change your settings later.

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